AAV

Patent Granted Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell although some integration of virally carried genes into the host genome does occur. [1] These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models.