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Patent Granted A macromolecule is a very large molecule commonly created by polymerization of smaller subunits. In biochemistry, the term is applied to the three conventional biopolymers (nucleic acids, proteins, and carbohydrates),[2] as well as non-polymeric molecules with large molecular mass such as lipids and macrocycles. The individual constituent molecules of polymeric macromolecules are called monomers (mono=single, meros=part).