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Syk inhibition

Patent Granted Syk inhibition has also been proposed as a therapy for both lymphoma and chronic lymphocytic leukemia.[6] Other inhibitors of B-cell receptor (BCR) signaling including ibrutinib (PCI-32765) which inhibits BTK, and idelalisib (PI3K inhibitor - CAL-101 / GS-1101) showed activity in the diseases as well. Newer Syk inhibitors have entered the clinic and are also in clinical development (GS-9973).

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