Conditions related to α2δ subunit of VGCC

Patent Pending The α2δ gene forms two subunits: α2 and δ (which are both the product of the same gene). They are linked to each other via a disulfide bond and have a combined molecular weight of 170 kDa. The α2 is the extracellular glycosylated subunit that interacts the most with the α1 subunit. The δ subunit has a single transmembrane region with a short intracellular portion, which serves to anchor the protein in the plasma membrane. There are 4 α2δ genes: CACNA2D1 (CACNA2D1), CACNA2D2 (CACNA2D2), (CACNA2D3), (CACNA2D4).