Apolipoprotein B mRNA editing

Patent Granted The mRNA of this protein is subject to Cytidine to Uridine (C to U) site specific RNA editing. ApoB100 and ApoB48 are encoded by the same gene, however the differences in the translated proteins is not due to alternative splicing but is due to the tissue specific RNA editing event. ApoB mRNA editing was the first example of editing observed in vertebrates.[16] Editing of ApoB mRNA occurs in all placental Mammals.[17] Editing occurs post transcriptionally as the nascent polypeptides do not contain edited nucleosides.