Supressing microglial activation

Patent Pending One way to control neuroinflammation is to inhibit microglial activation. Studies on microglia have shown that they are activated by diverse stimuli but they are dependent on activation of mitogen-activated protein kinase (MAPK).[17] Previous approaches to down-regulate activated microglia focused on immunosuppressants.[17] Recently, minocycline (a tetracycline derivative) has shown down-regulation of microglial MAPK.