B lymphopoiesis culture system

Patent Granted B cells are formed and mature in bone marrow (and spleen). It is a good mnemonic aide that B cells are formed in the bone marrow, but it is a mere coincidence since B cells were first studied in the chicken's bursa of Fabricius and it is from this bursa that B cells get their name. These B cells then leave the bone marrow and migrate to peripheral lymphoid tissues, such as a lymph node. Once in a secondary lymphoid organ the B cell can be introduced to an antigen that it is able to recognize.