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Patent Pending A homologation reaction, also known as homologization, is any chemical reaction that converts the reactant into the next member of the homologous series. A Homologous series is a group of compounds that differ by a constant unit, generally a (-CH2-) group. The reactants undergo a homologation when the number of a repeated structural unit in the molecules is increased. The most common homologation reactions increase the number of methylene (-CH2-) units in saturated chain within the molecule.