Insulin degrading enzymes

Patent Pending Insulin-degrading enzyme, also known as IDE is a human enzyme.[1] Known alternatively as insulysin or insulin protease, Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago,[2] though the enzyme specifically responsible for B chain cleavage was identified more recently.