Bacterial IMPDH

Patent Granted IMP dehydrogenase EC 1.1.1.205 (Inosine-5'-monophosphate dehydrogenase) (Inosinic acid dehydrogenaseis) (IMPDH) an enzyme that converts inosine monophosphate to xanthosine monophosphate:[2][3][4][5] inosine 5'-phosphate + NAD+ + H2O \rightleftharpoons xanthosine 5'-phosphate + NADH + H+ It catalyzes the rate-limiting reaction of de novo GTP biosynthesis.[6] IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans.[7] IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.