HIP1 cancer markers

Patent Pending HIP1 has also been found to be overexpressed in some cancers including a subset of colorectal and prostate cancers.[6] This is of specific interest because prostate cancer disease progression involves altered transcription/expression of the androgen receptor (AR).[7] The AR is a nuclear hormone receptor transcription factor that contains polyglutamine repeats. In 2005 Mills and colleagues showed that HIP1 is able to regulate transcription of hormone receptors via the androgen response element (ARE) and also alters the rate of degradation of the AR.