Neuron-restrictive silencer factor

Patent Granted RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor.[1][2][3] REST is expressly involved in the repression of neural genes in non-neuronal cells.[4][3] Many genetic disorders have been tied to alterations in the REST expression pattern, including colon and small-cell lung carcinomas found with truncated versions of REST.