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Patent Pending Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein-2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily.