AGR2 gene

Patent Pending Anterior gradient protein 2 homolog (AGR-2), also known as secreted cement gland protein XAG-2 homolog, is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis.[1] In Xenopus AGR2 plays a role in cement gland differentiation,[2] but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response,[3] cell migration, and cell transformation.[4] However, there have been other observations that AGR2 can repress growth and proliferation.