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Patent Granted Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with system name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction (-)-secoisolariciresinol + 2 NAD+ \rightleftharpoons (-)-matairesinol + 2 NADH + 2 H+ This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.