Geranylgeranyl diphosphate synthase

Patent Granted Geranylgeranyl pyrophosphate synthetase is an enzyme that in humans is encoded by the GGPS1 gene.[1][2][3] This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.