Selectively functionalized alkane

Patent Pending Electron density is a major factor in determining which C-H bond is most activated, and hence most reactive toward C-H functionalization reactions. Typically, the C-H bond that is most electron rich is the most reactive.The substitution of the carbon influences the electron density, such that tertiary carbons are the most electron rich and methyl is the least electron rich (most electron poor). The trend is as follows: tertiary>secondary>primary>methyl.