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Patent Granted CPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA.[1] CPEB most commonly activates the target RNA for translation, but can also act as a repressor,[2] dependent on its phosphorylation state.[3] In animals, CPEB is expressed in several alternative splicing isoforms that are specific to particular tissues and functions, including the self-cleaving Mammalian CPEB3 ribozyme.