Progesterone receptor membrane component 1

Patent Pending Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary.[1][2] In humans, the PGRMC1 protein is encoded by the PGRMC1 gene.[3] The Sigma-2 receptor was recently identified as potentially being the same as PGRMC1.[4] The sole biochemical function of PGRMC1 is heme-binding.[5][6] PGRMC1 shares key structural motifs with cytochrome b5.[7] PGRMC1 binds and activates P450 proteins,[8][9][10] which are important in drug, hormone and lipid metabolism.