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Patent Pending Plants have evolved R genes (resistance genes) whose products allow recognition of specific pathogen effectors, either through direct binding or by recognition of the effector's alteration of a host protein.[4] These virulence factors drove co-evolution of plant resistant genes to combat the pathogens’ Avr (avirulent) genes. Many R genes encode NB-LRR proteins (nucleotide-binding/leucine-rich repeat domains, also known as NLR proteins or STAND proteins, among other names).