Tumor suppressor gene ING1

Patent Granted Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3] This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.