IKK in yeast

Patent Pending The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.[1] The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.