Because of the Akt[1] functions above, Akt inhibitors may treat cancers such as neuroblastoma. Some Akt inhibitors have undergone clinical trials. In 2007 VQD-002 had a phase I trial.[26] In 2010 P...
Conceptually, there are two main types of NET within this category: those which arise from the gastrointestinal (GI) system and those that arise from the pancreas. In usage, the term "carcinoid" ha...
Cancer Listeni/ˈkænsər/, also known as a malignant tumor or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the bo...
Polymer drug conjugates are products of Nano-medicine enrolled in cancer diagnosis and treatment. There are more than 10 anticancer conjugates in clinical development. Polymer-drug conjugates are d...
Catalytic iridium complexes
Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular beating.[1] Often it starts as brief periods of abnormal beating which become longer and possibly ...
The crcB RNA motif (now called the fluoride riboswitch) is a conserved RNA structure identified by bioinformatics in a wide variety of bacteria and archaea.[1] These RNAs were later shown to functi...
Certain variations of the BRCA1 gene lead to an increased risk for breast cancer as part of a hereditary breast-ovarian cancer syndrome. Researchers have identified hundreds of mutations in the BRC...
An antimicrobial is an agent that kills microorganisms or inhibits their growth.[1] Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, a...
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.[2] ...
An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which weakness in the wall of a cerebral artery or vein causes a localized dilation or ballooning ...
Single-port laparoscopy (SPL), also known as single-port access surgery (SPA), single-port incisionless conventional equipment-utilizing surgery (SPICES), single-incision laparoscopic surgery (SILS...
Transient interference suppression
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophage...
Pseudobase benzo[c]phenanthridines
Nanomaterials describe, in principle, materials of which a single unit is sized (in at least one dimension) between 1 and 1000 nanometers (10−9 meter) but is usually 1—100 nm (the usual definition ...
Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms...
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being.[1][2] People with depressed mood can feel sad, anxious, e...
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assist...
Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalyst.[1] With a catalyst, reactions occur faster and with less energy. ...
