ANTI-HISTIDINE TAG DNA APTAMERS FOR BIOTECHNOLOGICAL APPLICATIONS

Technology The subject of the offer are unique sequences of single-stranded DNA aptamers that recognize His-Tag and their application in biotechnology in analysis of His-Tagged molecules (peptides, proteins or DNA derivatives). The offered DNA aptamers can be used for analysis of molecules containing a His-Tag, and in particular to: • application as a agonist for anti-histidine antibodies; • purification and detection of the target molecules containing a His-Tag. In addition to the above applications, DNA aptamers can be used as molecules with attached tags, especially fluorescent, and in particular to label the molecular targets containing His-Tag. This type of molecules can be successfully used e.g. to study the interaction between proteins using spectroscopic techniques.