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特許 係属中 PROBLEM TO BE SOLVED: To develop new treatment method and prevention method for the Alzheimer disease that are safe and highly-effective, and to provide techniques that contribute to the development. ; SOLUTION: According to the present invention, protein groups bonded with amyloid [beta] protein have been given comprehensively, by utilizing proteomics technique. Knowledge regarding these protein groups is considered to contribute significantly to the possibility of developing curative medicine targeted at such protein groups, as well as, of causal breakthrough of the Alzheimer disease.