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特許 権利維持 Hereditary Spastic Paraplegia (HSP), also know as Hereditary Spastic Paraparesis, Familial Spastic Paraplegias, French Settlement Disease, or Strumpell-Lorrain Disease, is a group of inherited diseases whose main feature is progressive stiffness and contraction (spasticity) in the lower limbs,[1] as a result of damage to or dysfunction of the nerves.