PRC2

特許 係属中 PRC2 (Polycomb Repressive Complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1. This complex has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27 (i.e. H3K27me3),[1][2] a mark of transcriptionally silent chromatin. PRC2 is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of silenced region after cellular differentiation.