PI3K lipid kinase inhibitors

特許 権利維持 As wortmannin and LY294002 are broad inhibitors against PI 3-kinases and a number of unrelated proteins at higher concentrations they are too toxic to be used as therapeutics.[citation needed] A number of pharmaceutical companies have recently been working on PI 3-kinase isoform specific inhibitors including the class I PI 3-kinase, p110δ isoform specific inhibitors, IC486068 and IC87114, ICOS Corporation.[citation needed].GDC-0941 is a highly selective inhibitor of p110α with little activity against mTOR.