sLRP

特許 権利維持 Neurons require cholesterol to function. Cholesterol is imported into the neuron by apolipoprotein E (apoE) via LRP1 receptors on the cell surface. It is thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol.[3] Soluble low-density lipoprotein receptor-related protein (sLRP) is a biological substance naturally produced by the human body.[1][2] This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma.[3] Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's Disease.