Polymorphism of serotonin transporter gene promoter

特許 権利維持 The serotonin transporter (SERT or 5-HTT) is a type of monoamine transporter protein that transports serotonin from the synaptic cleft to the presynaptic neuron. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class.[1] It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.