Apolipoprotein E2

特許 係属中 E2 (rs7412) has an allele frequency of approximately 7 percent.[13] This variant of the apoprotein binds poorly to cell surface receptors while E3 and E4 bind well.[14] E2 is associated with both increased and decreased risk for atherosclerosis. Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia—94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age).[15][16][17] E2 has also been implicated in Parkinson's disease.[18] E2 is no longer associated with Parkinson disease in a larger population association study.