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特許 係属中 IMP dehydrogenase EC 1.1.1.205 (Inosine-5'-monophosphate dehydrogenase) (Inosinic acid dehydrogenaseis) (IMPDH) an enzyme that converts inosine monophosphate to xanthosine monophosphate:[2][3][4][5] inosine 5'-phosphate + NAD+ + H2O \rightleftharpoons xanthosine 5'-phosphate + NADH + H+ It catalyzes the rate-limiting reaction of de novo GTP biosynthesis.