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特許 権利維持 WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4[1] (HE4) - is a protein that in humans is encoded by the WFDC2 gene.[2][3][4] HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L.