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特許 係属中 A hydrogenase is an enzyme that catalyses the reversible oxidation of molecular hydrogen (H2), as shown below: (1) H2 + Aox → 2H+ + Ared (2) 2H+ + Dred → H2 + Dox Hydrogen uptake (1) is coupled to the reduction of electron acceptors such as oxygen, nitrate, sulfate, carbon dioxide, and fumarate.