Active site protease inhibitors

特許 係属中 Identification of active sites is crucial in the process of drug discovery. The 3-D structure of the enzyme is analysed to identify active sites and design drugs which can fit into them. Proteolytic enzymes are targets for some drugs, such as protease inhibitors, which include drugs against AIDS and hypertension.[6] These protease inhibitors bind to an enzyme's active site and block interaction with natural substrates.[7] An important factor in drug design is the strength of binding between the active site and an enzyme inhibitor.