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特許 権利維持 Photoaging or photoageing[1] (also known as "dermatoheliosis"[2]) is a term used for the characteristic changes to skin induced by chronic UVA and UVB exposure.[3]:29 Tretinoin is the best studied retinoid in the treatment of photoaging[4] The deterioration of biological functions and ability to manage metabolic stress is one of the major consequences of the aging process.