Asymmetric cyclopropanation

特許 係属中 While cyclopropane is achiral, substituted cyclopropanes very often display chirality. The presence of the cyclopropane motif in a number of drug molecules has made the development of enantioselective synthesis important. In general the chirality of metal catalysed intermolecular processes can be controlled by use of chiral ligands[18] or chiral auxiliaries.[6] other processes may be influenced by asymmetric induction; this area has been reviewed.