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特許 権利維持 Tobacco smoking is the most common cause of COPD, with a number of other factors such as air pollution and genetics playing a smaller role.[3] In the developing world, one of the common sources of air pollution is from poorly vented cooking and heating fires. Long-term exposure to these irritants causes an inflammatory response in the lungs resulting in narrowing of the small airways and breakdown of lung tissue known as emphysema.