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特許 係属中 The Herpes simplex virus is a human neurotropic virus. This is mostly examined for gene transfer in the nervous system. The wild type HSV-1 virus is able to infect neurons and evade the host immune response, but may still become reactivated and produce a lytic cycle of viral replication. Therefore it is typical to use mutant strains of HSV-1 that are deficient in their ability to replicate.
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