TRPV1 receptor agonists

特許 係属中 Agonists such as capsaicin and resiniferatoxin activate TRPV1 and, upon prolonged application, TRPV1 activity would decrease (desensitization), leading to alleviation of pain. Agonists can be applied locally to the painful area as through a patch or an ointment. Numerous capsaicin-containing creams are available over the counter, containing low concentrations of capsaicin (0.025 - 0.075%). It is debated whether these preparations actually lead to TRPV1 desensitization; it is possible that they act via counter-irritation.