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特許 権利維持 Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.[1] It is secreted by cells of the floor plate and may be involved in axon guidance[2] The protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.