Keap1-Nrf2 interaction

特許 係属中 Keap1 has been shown to interact with: Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of and oxidative stress.[2][3][4] Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2.