Lacritin

特許 係属中 Lacritin is a 12.3 kDa glycoprotein encoded in humans by the LACRT gene.[1][2] Lacritin's discovery emerged from an unbiased screen for novel factors that stimulate tear protein secretion.[2][3] Lacritin is a secreted protein found in tears and saliva. Lacritin also promotes tear secretion,[2][4] the proliferation[2] and survival of epithelial cells,[5] and corneal wound healing[6] Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity. Natural or bacterial cleavage of lacritin releases a C-terminal fragment that is bactericidal.