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特許 権利維持 Drug resistance is the reduction in effectiveness of a drug such as an antimicrobial, anthelmintic or an antineoplastic[1] in curing a disease or condition. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. More commonly, the term is used in the context of resistance that pathogens have "acquired", that is, resistance has evolved.