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Patent Pending Disclosed is a composition which can regulate the activity of a bone-forming protein involved in the formation of a bone tissue or a cartilage tissue. Specifically disclosed are: a regulator of the activity of a bone-forming protein, which comprises a sulfated galactosaminoglycan having 0.6 piece or more ester sulfate group on average per one constituent monosaccharide or a salt thereof as an active ingredient.
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