Prion disease treatment

Patent Pending PROBLEM TO BE SOLVED: To provide a screening method for rapidly, easily, and efficiently retrieving a low molecule curing candidate compound to a prion disease, and to provide a prion disease curative medicine. ; SOLUTION: This screening method of the prion disease curative medicine indexes the inhibition of bonding of sugar including a disaccharide structure constituting a sulfated polysaccharide to a normal prion protein fragment containing at least amino acid sequence of N terminal regions digested and removed by protease processing of abnormal prion protein, or overall length normal prion protein.