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Patent Granted Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).[1][2] Such abnormalities can be identified in 50% of people who have an episode of thrombosis (such as deep vein thrombosis in the leg) that was not provoked by other causes.[3] A significant proportion of the population has a detectable abnormality, but most of these only develop thrombosis in the presence of an additional risk factor.