Estrogen receptor ligands

特許 係属中 The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand.[13][14] Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors [need citations] estrone, and raloxifene bind preferentially to the alpha receptor [need citations] estriol, and genistein to the beta receptor [need citations]