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Patent Pending The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand.[13][14] Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors [need citations] estrone, and raloxifene bind preferentially to the alpha receptor [need citations] estriol, and genistein to the beta receptor [need citations]
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