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Patent Pending In medicine, ischemia, also spelled as ischaemia or ischæmia[a] (/ɪˈskiːmɪə/[1][2]), is a restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism (to keep tissue alive).[3] Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue. It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism).